Weight & metabolism

Why is weight harder to lose after 40? Medical answers in Winter Garden

Many adults find weight settling around the middle in their 40s, even when eating and exercise haven't changed. It isn't a willpower problem. We look at muscle, hormones, metabolism, sleep, and medications to understand what is driving it, then build a plan you can keep.

What might be going on

Midlife weight gain usually has several causes working together:

  • Gradual muscle loss with age, which lowers how many calories your body uses
  • Hormone shifts, such as menopause in women and lower testosterone in some men, though hormones are rarely the whole story
  • Shorter or poorer sleep, chronic stress, and less activity
  • Insulin resistance, an underactive thyroid, or medications such as steroids and some antidepressants

How we evaluate it

Your consultation covers weight history, eating and activity patterns, sleep, stress, medications, and goals. Metabolic labs may include blood sugar, cholesterol, thyroid, and hormone markers. We also measure body composition, so we can track fat and muscle, not just the scale. Dr. Chander explains which options, if any, are appropriate for you.

Treatments we offer

Nutrition, strength training, and sleep are the foundation. Prescription medications can cause nausea and constipation. They aren't right for everyone. Examples include people with a personal or family history of medullary thyroid cancer or MEN 2, or who are pregnant or planning pregnancy. When appropriate, we may add:

  • Semaglutide — a once-weekly GLP-1 injection that reduces appetite alongside lifestyle changes
  • Tirzepatide — a once-weekly dual GIP/GLP-1 injection that works on two gut-hormone pathways
  • Hormone Therapy for Women — for menopausal symptoms like night sweats and poor sleep that can make weight harder to manage
  • Testosterone Therapy for Men — only when symptoms and labs confirm low testosterone, which can reduce muscle mass

When to see your doctor first

Call 911 for chest pain, severe shortness of breath, or fainting.

See your primary care doctor first if weight gain comes with swollen feet or ankles, new shortness of breath, or very rapid gain. Constipation, hair loss, or feeling unusually cold can point to thyroid problems. Tell us about any recent medication change.

Ready to talk it through? Book a Complimentary Consultation. Dr. Chander will review your history and goals and tell you plainly which options fit and which do not.

Questions

Common questions

Who qualifies for a weight-loss medication?

Adults with a BMI of 30 or higher, or 27 or higher with a weight-related condition, may be candidates. Dr. Chander decides after reviewing your history and labs.

Will I lose muscle?

Some of the weight lost can be muscle. That's why we track body composition and pair medication with protein targets and strength training.

What about retatrutide?

Retatrutide is investigational and not FDA-approved, so we do not offer it. We follow the research and will discuss it if it becomes an approved option.

Get started

Let's figure out what's behind it.

Book a complimentary consultation — we'll review your symptoms and history and map out the right next step, even if that step is a referral.

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